Retatrutide

Retatrutide (LY3437943) is a synthetic peptide investigated in research for its effects on metabolic regulation. It functions as a triple agonist of the glucagon receptor (GCGR), glucagon-like peptide-1 receptor (GLP-1R), and glucose-dependent insulinotropic polypeptide receptor (GIPR) (receptors involved in appetite control, glucose regulation, and energy balance). In laboratory studies, it is characterised by strong receptor binding affinities, with reported EC₅₀ values of 5.79 nM (GCGR), 0.775 nM (GLP-1R), and 0.0643 nM (GIPR). Owing to this multi-receptor activity, retatrutide is studied as a model compound for exploring mechanisms related to metabolism, body weight regulation, and energy homeostasis.